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Cleveland-A Harvard Medical School study published last year in JAMA (2005; 293:455-62) established a link between obesity and kidney stone formation. Now researchers at the University of Minnesota have taken the next step with a study showing that obese men and women have at least one, if not more, urine abnormalities that increase their risk of stone formation.

Cleveland-There is a commonly held view that obese patients tend to present greater surgical challenges and have more complications after percutaneous nephrolithotomy. Researchers from Albert Einstein College of Medicine in New York have challenged that belief.

Cleveland-Intravenous ketorolac tromethamine is safe and appears to be effective at alleviating pain following percutaneous nephrolithotomy (PNL) procedures in properly selected patients, according to a study from the Methodist Hospital Institute for Kidney Stone Disease and Indiana University School of Medicine, Indianapolis.

Boston-A study investigating a treatment sample of men diagnosed with sexual compulsivity suggests that prescription and non-prescription use of phosphodiesterase type-5 inhibitors is common in that population. This finding should alert physicians who prescribe medications for erectile dysfunction to maintain an index of patients with a suspected sexual compulsivity problem and to be attentive to clues of potential drug misuse, according to the researchers.

Ann Arbor, MI-Results of a study from the University of Michigan here provide further evidence that the incidence of kidney cancer and the rate of surgical treatment are both on the rise. However, those trends are primarily accounted for by the identification and management of small, presumably curable renal masses (?4 cm). Meanwhile, mortality rates in kidney cancer patients have also been increasing, driven by worsening outcomes of patients with the largest tumors (>7 cm).

Washington-Trichloroethylene (TCE) is a chlorinated hydrocarbon once commonly used as a degreasing agent in industrial settings. The nonflammable, colorless fluid may also be found as an ingredient in adhesives, paint removers, typewriter correction fluids, and spot removers. Although a clear-cut link between TCE and cancer has yet to be established, the chemical is the subject of a recent report calling for research on how it causes cancer and other adverse health effects.

Cleveland-Two studies from the University of Minnesota and one from the University of Tennessee presented at the World Congress of Endourology tackled three important questions raised by the use of nephrostomy tubes: Which configuration best minimizes pain? How small can the tube be and remain effective? When can a nephrostomy tube be abandoned altogether?

The return and quality of sexual function is a major concern for men undergoing radical prostatectomy. New research on the etiology of post-prostatectomy erectile dysfunction is shaping new rehabilitation strategies for prostatectomy patients, according to John P. Mulhall, MD, who discusses current and future rehabilitation strategies and his own approach to post-prostatectomy ED in this exclusive interview.

Boston-Gonadotropin-releasing hormone (GnRH) agonist therapy for locoregional prostate cancer is associated with significantly increased risks of diabetes as well as cardiovascular disease morbidity and mortality, according to the results of a population-based, observational cohort study.

It is not enough to maintain control over the profitability of your practice. In order to gain control, you need to know the cost of each procedure you perform in the office, the reimbursement from each of your payers, and the profit margin for each service you offer your patients.

Indevus Pharmaceuticals, Inc. has submitted a new drug application to the FDA seeking approval for a once-daily formulation of trospium chloride (Sanctura XR) to treat patients with overactive bladder.

Treatment with the investigational agent toremifene citrate (Acapodene) decreased the incidence of prostate cancer by 1 year in patients with high-grade prostatic intraepithelial neoplasia, according to a study published recently in the Journal of Urology (2006; 176:965-71).

Patients with BPH who were treated with the investigational drug NX-1207 showed a total pooled mean improvement of 9.35 points in the primary outcome endpoint of AUA Symptom Score values at 3 months, researchers from Nymox Pharmaceutical Corp. reported.

Physicians should consider the impact of a patient's body mass index, regardless of race, when interpreting prostate cancer screening test results, according to the authors of a study to be published in Cancer.

New Products & Services

Irvine, CA-The Cryocare CN2 System from Endocare, Inc. has received 510K clearance from the FDA. The device uses the freezing capability of nitrogen at the point between gas and liquid-"critical nitrogen"-to destroy cancerous tissue quicker and more cost-effectively than argon can, according to the manufacturer. The speed and precision of this new technology can expedite procedures, Endocare says, because it is easy to use and it delivers a colder, more powerful ice ball at the end of the probes.

New Products & Services

Irvine, CA-The Cryocare CN2 System from Endocare, Inc. has received 510K clearance from the FDA. The device uses the freezing capability of nitrogen at the point between gas and liquid-"critical nitrogen"-to destroy cancerous tissue quicker and more cost-effectively than argon can, according to the manufacturer. The speed and precision of this new technology can expedite procedures, Endocare says, because it is easy to use and it delivers a colder, more powerful ice ball at the end of the probes.

Preston, United Kingdom-MRI scans proved to be an effective way to diagnose colo-vesical fistula in patients in a small study from the United Kingdom. The MRI group was compared with a retrospective group of patients who had been previously treated for the condition.

Cleveland-If you could see into a kidney, prostate gland, or bladder and know the extent of tumor penetration, the precise location of nerve bundles and blood vessels, or the exact depth and angle of your blade vis-?is the tumor at any given moment, how would it change surgery for you?

Minneapolis-For men suffering from the most common sexual dysfunction, premature ejaculation, an investigational drug therapy may offer improved control over ejaculation and sexual satisfaction with a relatively low incidence of side effects.

San Antonio-The Prostate Cancer Prevention Trial (PCPT) showed conclusively that finasteride (Proscar), a 5-alpha-reductase inhibitor indicated for the treatment of BPH, reduced the incidence of prostate cancer by nearly 25%. Continuing analysis of data from that trial now show the drug also enhances detection of prostate cancer by significantly improving the specificity of the PSA assay, according to a study published recently in the Journal of the National Cancer Institute (2006: 98:1128-33).

New Hyde Park, NY-As difficult as laparoscopic cases in urology are now, the complication rates have not increased, according to a retrospective chart analysis of the complications associated with nearly 3,000 laparoscopic procedures at a high-volume center. The data, compiled over a 12-year period at Johns Hopkins Medical Institutions, Baltimore, were reported at the 2006 AUA annual meeting in Atlanta.