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Atlanta-Combining an alpha-blocker with a phosphodiesterase-5 (PDE-5) inhibitor appears to produce a greater therapeutic benefit in men with lower urinary tract symptoms than either drug alone, according to a study from Weill Cornell Medical College, New York.

Chicago-A widely studied protein can help urologists find sperm to be used for in vitro fertilization and may even indicate another future pharmaceutical application of the substance, according to research presented here at the American Society of Andrology annual meeting here.

Atlanta-Chronic prostatic inflammation may increase the chance that a man will develop prostate cancer, suggesting that men with inflammation on biopsy may need to be followed more closely and perhaps even be re-biopsied more aggressively, even if there is no evidence of cancer.

Best of AUA

Among the more than 1,700 scientific papers presented at the 2006 AUA annual meeting, the focus was less on new medical or procedural innovations than on the benefits and risks of current tests and therapies.

American Medical Systems Holdings Inc. and Laserscope, two companies with a significant presence in the urology market, have entered into a definitive merger agreement providing for the acquisition of Laserscope by AMS.

A combination of sipuleucel-T (Provenge) active cellular immunotherapy for prostate cancer and bevacizumab (Avastin) significantly increased the PSA doubling time in patients with prostate cancer who had relapsed after prior surgical and radiation therapy, according to recently published data from the Cleveland Clinic Taussig Cancer Center and the University of California, San Francisco.

Brisbane, Australia-Decisions about when and how to perform prostate biopsy have become more complex in recent years, said Michael Jewett, MD, professor of surgery (urology), University of Toronto, in an address at the Urological Society of Australasia annual meeting here. The objective of biopsy should be to detect prostate cancer in men who will benefit from the information they yield.

Paris-Once-daily administration of a newer alpha-blocker appears to have a positive effect in the treatment of patients suffering from lower urinary tract symptoms and BPH compared with placebo, but comes up short in preventing acute urinary retention occurrence, according to Claus G. Roehrborn, MD, professor and chairman of the department of urology at the University of Texas Southwestern Medical Center, Dallas. Dr. Roehrborn presented the results of a 2-year study at the European Association of Urology annual congress here.

Paris-In patients with lower urinary tract symptoms due to bladder outlet obstruction, targeted high-energy transurethral microwave thermotherapy (TUMT) provides a suitable option for improvement of their condition, according to Bob Djavan, MD, who presented the results of an 8-year, multicenter, European study at the European Association of Urology annual congress here.

Atlanta-The debate over the most appropriate surgical approach for placement of an artificial urinary sphincter (AUS) may be coming to a resolution. In the largest retrospective trial reported to date, Gerard D. Henry, MD, a urologist with Regional Urology, Shreveport, LA, found that the traditional perineal approach offers significantly better urinary control than the newer penoscrotal insertion approach.

Atlanta-Intravesical administration of an agent that is chemically related to cannabis produces a positive response in laboratory rats and may be useful in patients with painful bladder syndrome/interstitial cystitis, investigators from the University of Pittsburgh reported at the AUA annual meeting.

Five states failed the first-ever prostate cancer state-by-statereport card issued by the National Prostate Cancer Coalition.Alabama, Arkansas, Idaho, Mississippi, and Wisconsin did not makethe grade while California, Connecticut, Kansas, and New York allearned As.

Washington-A recent report by Medicare trustees warning that the program will run out of money by 2018, 2 years earlier than previously predicted, can be expected to make it more difficult for Medicare physicians to avoid payment reductions and could expedite implementation of the controversial pay for performance (P4P) reforms.

Product Preview

Cell Genesys Inc.'s GVAX immunotherapy for prostate cancer has been granted fast-track status from the FDA. The product is involved in two phase III trials, which are designed to show survival benefit with GVAX versus docetaxel (Taxotere) plus prednisone (Deltasone, Meticorten, Orasone, et al). The studies involve 1,200 men with metastatic hormone-refractory prostate cancer. Both have received special protocol assessments from FDA.

Brisbane, Australia-Intravesical instillation of certain drugs has proven to be safe in reducing stent-related symptoms in patients undergoing ureteroscopy, and drug-eluting stents could eventually become a new treatment paradigm for other urologic disorders, such as bladder cancer and interstitial cystitis, said John Denstedt, MD, professor of urology, University of Western Ontario, London, ON. Dr. Denstedt discussed current research in stent technology and prospects for the future in a presentation at the Urological Society of Australasia annual meeting here.