Opinion

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Clinical Perspectives from the ARANOTE Trial in Metastatic Hormone-Sensitive Prostate Cancer

Key Takeaways

  • Darolutamide's structure limits blood-brain barrier penetration, reducing central nervous system side effects and improving safety.
  • It effectively delays metastasis and prolongs survival in non-metastatic castration-resistant prostate cancer.
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Fred Saad, CQ, MD, FRCS, FCAHS, discusses how darolutamide offers potential advantages over other androgen receptor–targeted therapies for metastatic prostate cancer, including its unique molecular structure, favorable safety profile, and efficacy in specific clinical scenarios.

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