Evaluating Real-World Evidence and Clinical Endpoints in mCSPC

This episode, titled “Evaluating Real-World Evidence and Clinical Endpoints in mCSPC,” features panelists examining how clinicians assess comparative datasets and interpret clinical endpoints when making treatment decisions for patients with metastatic castration-sensitive prostate cancer (mCSPC). As real-world evidence (RWE) becomes increasingly integrated into oncology research, the expert faculty discuss both the strengths and limitations of these analyses and how they complement findings from prospective clinical trials.

The panel of experts examines how real-world and comparative studies can inform treatment decisions in mCSPC while acknowledging the limitations inherent in non-randomized research. They discuss how differences in patient populations and treatment patterns can influence outcomes and emphasize the importance of critically evaluating study design when translating evidence into clinical practice. While real-world evidence can broaden understanding beyond traditional clinical trials, careful interpretation remains essential to ensure appropriate application to individual patients.

In addition, the expert faculty discuss the relative importance of clinical endpoints used to evaluate ARPI-based therapies, including overall survival, PSA90 response, time to metastatic castration-resistant disease, and time to next treatment. They review the growing evidence linking deep and durable PSA responses with long-term outcomes and discuss how consistency of findings across multiple datasets can strengthen confidence in observed treatment effects and support clinical decision-making in mCSPC.

The next episode in this series, ‘Challenges with Integrating Real-World Evidence for ARPI Use in mCSPC,’ features the panelists discussing how real-world evidence, treatment adherence, dosing requirements, steroid use, bioavailability, and food administration considerations influence treatment decisions and outcomes in mCSPC. They also examine key biases in comparative analyses and highlight practical strategies for optimizing ARPI use in everyday clinical practice.