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Opinion|Videos|June 5, 2024

Exploring Treatments for BCG-Unresponsive Intermediate-High Risk NMIBC

Expert urologist explores potential treatments for BCG-unresponsive intermediate and high-risk non-muscle-invasive bladder cancer (NMIBC), including immune checkpoint inhibitors, oncolytic viral therapy, cytokine agonists, immunomodulators, and the recently approved drugs pembrolizumab and nogapendekin alfa inbakicept-pmln.

Episodes in this series

Video 1 "Unmet Needs & Standard of Care for Intermediate-High Risk NMIBC"

EP. 1 Unmet Needs & Standard of Care for Intermediate-High Risk NMIBC

Video 2 - "Exploring Treatments for BCG-Unresponsive Intermediate-High Risk NMIBC"

EP. 2 Exploring Treatments for BCG-Unresponsive Intermediate-High Risk NMIBC

Gary D. Steinberg, MD, an expert on bladder cancer

EP. 3 Intravesical Novel Therapy for HR BCG-Unresponsive NMIBC

Gary D. Steinberg, MD, an expert on bladder cancer

EP. 4 AUA 2024: Outlining BOND-003 Data for NMIBC Therapy

Gary D. Steinberg, MD, an expert on bladder cancer

EP. 5 BOND-003: Clinical Implications for HR BCG-Unresponsive NMIBC Treatment

Gary D. Steinberg, MD, an expert on bladder cancer

EP. 6 AUA 2024: Key Takeaways & Future of NMIBC Management

Can you discuss some of the exploratory treatments for BCG‐unresponsive intermediate and high risk‐NMIBC? (eg. immune checkpoint inhibitors (ICI), oncolytic viral therapy, cytokine agonists, and other immunomodulators)
BCG‐unresponsiveness (definition?)
1. Include (recently) approved immunotherapies: pembrolizumab, nogapendekin alfa inbakicept-pmln
Gene therapy: nadofaragene firadenovec

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