Opinion|Videos|April 14, 2026

Navigating Prior Authorization Denials and Appeals in mCRPC

In this episode, ‘Navigating Prior Authorization Denials and Appeals in mCRPC,’ the expert faculty explore the following questions:
1. What best practices do you recommend to ensure accuracy when completing prior authorization forms and avoid preventable denials in mCRPC?

  1. How do you communicate prior authorization denials and next steps to prescribing clinicians, and how do you address the misconception that a denial means a therapy is not covered in mCRPC?

2. What prior authorization or coverage challenges have you encountered when prescribing ARPIs, including certain formulations of ARPI, and other therapies in mCRPC?

3. What are the most common reasons for denials, and how do step therapy requirements or formulation restrictions contribute to these access challenges in your experience?

4. How often do you appeal prior authorization denials, and how successful are these appeals?

What strategies have been effective when appealing denials for therapies used in mCRPC


The panelist examined the practical strategies to improve prior authorization success for therapies used in metastatic castration-resistant prostate cancer (mCRPC). Faculty will discuss the use of structured templates to ensure complete and accurate documentation, as well as the importance of understanding payer-specific questions and intent. Common causes of denials, including incomplete clinical documentation and misinterpretation of payer criteria, will be explored. Participants will also review effective approaches to managing denials, including translating payer feedback into actionable next steps and structuring targeted appeals. Real-world insights will highlight how consistent appeal strategies and precise documentation can significantly improve approval rates and patient access to therapy.

The next episode in this series, ‘Operational Best Practices To Improve Access in mCRPC,’ the panelist focuses on workflow strategies to improve timely access to therapies in mCRPC, including prior authorization timing, documentation practices, and operational efficiencies. Faculty will share practical insights to reduce delays and support patient-centered care.