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Botulinum toxin A (Botox) injections show potential for providing a quick, easy, and safe treatment option for men with lower urinary tract symptoms related to BPH, but two small studies presented yesterday provided equivocal results regarding the efficacy of this investigational approach. U.S. researchers tested their 10-minute, ultrasound-guided technique in a two-part study. In the first part, 10 patients were injected with botulinum, 100 units, to assess safety, International Prostate Symptom Score, flow rates, and bother scores. In the second part, 30 patients received 200 units of botulinum in a sham-controlled, double-blind study, and sequential MRIs were taken pretreatment and at 1 and 3 months post-treatment to measure prostate volume.

Genitofemoral (GF) nerve grafting during radical retropubic prostatectomy can be performed safely with a low risk of postoperative morbidity and shows promising efficacy for returning erectile function after surgery involving wide nerve resection, according to the results of a retrospective study undertaken by urologists from Vanderbilt University, Nashville, TN.

Istanbul, Turkey--Swiss data add to growing evidence that injecting botulinum toxin A (Botox) into the detrusor muscle is a safe and efficient treatment option in patients suffering from overactive bladder, particularly in cases that prove refractory to other more conventional treatment modalities, like anticholinergic agents and physiotherapy.

Orlando, FL--Testosterone's effect on the development and progression of BPH and prostate cancer is well known, but a group of University of Tennessee researchers has been focusing on testosterone's less frequently studied "partner in crime"—estrogen.

A combination of brachytherapy and external radiation plus androgen deprivation gives prostate cancer patients with high-risk disease a better chance of survival than patients treated with radiation alone, according to a study in the International Journal of Radiation Oncology*Biology*Physics (2005; 61:32-43).

Paris--A novel adjustable device for intrinsic sphincteric deficiency shows success in women with stress unitary incontinence after other surgeries have failed, according to findings from an international, multicenter study.

Minnetonka, MN-The FDA has cleared for marketing American Medical Systems' 700 Tactile Pump, the latest addition to the AMS 700 line of penile prostheses.

Minnetonka, MN-The FDA has cleared for marketing American Medical Systems' 700 Tactile Pump, the latest addition to the AMS 700 line of penile prostheses.

San Francisco--Still known primarily for its ability to smoothfacial wrinkles, botulinum toxin A (Botox) is gaining acceptance as a treatmentoption for refractory overactive and neurogenic bladder.

Trimedyne's OmniPulse Holmium:YAG Laser utilizes DoublePulse technology,which delivers the ablation effect of two laser pulses with the acousticeffect of one pulse when treating renal stones. It also reduces potentialrisks of ureteral wall injury compared with normal pulsed operation, thecompany says.

Known primarily for smoothing facial wrinkles, botulinumtoxin A (Botox) is gaining acceptance as a treatment option for refractoryoveractive and neurogenic bladder. The latest evidence comes from the Universityof Pittsburgh School of Medicine, where a 110-patient review of the off-labeluse of botulinum toxin for those indications produced promising resultsin terms of both safety and efficacy.

Vienna, Austria--The first analysis of the Early Prostate Cancer program-presented3 years ago at the European Association of Urology annual congress-revealedthat the anti-androgen bicalutamide (Casodex), 150 mg, cuts prostate cancerprogression risk almost in half in patients with localized or locally advanceddisease. A second analysis, presented at this year's meeting, confirmedthat the earlier finding holds true whether patients are treated with radicalprostatectomy, radiotherapy, or watchful waiting.

FDA OKs treatment for men with testosterone deficiency. Livingston, NJ-The FDA has approved Columbia Laboratories' testosterone buccal system (Striant mucoadhesive) for testosterone replacement therapy. The transbuccal treatment is for men with conditions associated with a deficiency or absence of endogenous testosterone, including hypogonadism.

Chicago-New research on efforts to lower the infection rate among men receiving penile prostheses will likely change how urologists approach this challenging problem, say researchers from three leading Southeastern institutions.