5 key trial insights from AUA 2025
Hear from 5 experts as they recap some of the top data from this year's AUA.
Félix Guerrero-Ramos, MD, on TAR-200 in papillary disease-only NMIBC
“[These are] very good numbers for these patients who otherwise would undergo a radical cystectomy," says Félix Guerrero-Ramos, MD, PhD, FEBU.
AUA 2025 recap: Urologic oncology trials in progress
Take a look through some of the notable studies that were spotlighted during this year’s meeting.
Khurshid Ghani, MD, on trial of stent omission following ureteroscopy
The SOUL study is assessing patient-reported outcomes and unplanned health care utilization among patients who had stent placement vs stent omission after ureteroscopy.
Hugo robot-assisted surgery system shows promise for urologic procedures
These results are expected to support submission of the Hugo system to the FDA for use in urologic procedures.
TAR-200 elicits high complete response rate in BCG-unresponsive NMIBC
Data showed an overall CR rate of 82.4%.
Pearls & Perspectives: Evolving role of APPs in urology, with Corinna Hughes, DNP, at AUA 2025
Corinna Hughes, DNP, sits down with Amy Pearlman, MD, to discuss the evolving recognition of APPs in urology.
CISTO: Radical cystectomy has key role in recurrent high-grade NMIBC
Twelve-month physical functioning scores were comparable between the radical cystectomy arm and the bladder-sparing therapy arm.
Shreyas Joshi, MD, recaps AUA session on chemotherapy vs novel NMIBC options
“It is likely that more and more, these newer agents are going to play earlier and more central roles in the early treatment of BCG-unresponsive disease," says Shreyas S. Joshi, MD, MPH.
Pearls & Perspectives: Future of reconstructive urology, with Ryan Terlecki, MD, at AUA 2025
A discussion on evolution of surgical education, importance of video training, and the future of patient-centered care in reconstruction.
TAR-200 boasts impressive DFS rates in papillary disease-only NMIBC
Data showed a disease-free survival rate of 85.3% at 6 months and 81.1% at 9 months.
Shay Rajavel, MS3, on CO2 gas embolism during single-port partial nephrectomy
Shay Rajavel, MS3, shares details on an AUA 2025 presentation on CO2 gas embolism during laparoscopic surgery.
Kevin Zorn, MD, on preserving ejaculation with BPH therapies
Kevin C. Zorn, MD, FRCSC, FACS, recaps the AUA 2025 session, “State-of-the-Art Lecture: Preservation of Ejaculatory Function with BPH Treatments."
Pearls & Perspectives: Advancing sexual health in urology, with Rachel Rubin, MD, at AUA 2025
Rachel Rubin, MD, discusses advancements in sexual health education and guidelines at the AUA meeting.
Pearls & Perspectives: Innovation in male fertility care with Larry Lipshultz, MD, at AUA 2025
Discover groundbreaking insights in urology as Larry Lipshultz, MD, shares innovative research and strategies for male fertility challenges.
Ultra-low PSA responses are more prevalent with darolutamide plus ADT
The investigators reported that ultra-low PSA responses “were associated with prolonged rPFS and delayed progression to mCRPC and PSA progression.”
Neal Shore, MD, on sasanlimab plus BCG for BCG-naïve NMIBC
Neal D. Shore, MD, FACS, shares the background and key findings from the phase 3 CREST trial, exploring sasanlimab plus BCG for BCG-naive NMIBC.
Cxbladder Triage may help patients avoid unnecessary cystoscopies
The study population was able to avoid 952 cystoscopies and 70 CT scans, according to the investigators.
Investigational ProVee System impresses in phase 3 trial in BPH
No device- or procedure-related serious AEs were observed through 12 months across the entire study population
Alexander Glaser, MD, on real-world outcomes with Aquablation
Pearls & Perspectives: Martin Kathrins, MD, on MED3000 and learning from failed trials
Kathrins discusses the intricacies of leading a clinical trial and why "negative" trials are important to informing care strategies.
ARANOTE substudy highlights benefits of darolutamide in Black men
The investigators reported that treatment with darolutamide reduced the risk of radiological progression or death by 49% in Black men.
CVAC 2.0 demonstrates efficacy for clearing stones less than 2 cm
The investigators reported a median stone clearance of 96.44%.
Vitaly Margulis, MD, on preliminary safety, efficacy of padeliporfin VTP for UTUC
Vitaly Margulis, MD, shares his insights on initial data from the phase 3 ENLIGHTED trial.
AUA 2025: GLP-1 RAs could improve sperm count in overweight men
New research reveals GLP-1 receptor agonists may enhance sperm counts in overweight men.
Nogapendekin alfa inbakicept shows high CR, avoidance of cystectomy in NMIBC
In cohort A, the cystectomy-free rate at 36 months was 84%.
Pearls & Perspectives: Urology's role in GLP-1 RA treatments, with Hossein Sadeghi-Nejad, MD, and Nathalie Eid, BA
This episodes explores the evolving role of GLP-1 medications in testosterone management and their impact on male sexual health and fertility.
Most men in EMBARK trial recover T levels following treatment suspension
More than 80% of patients in both groups had a full recovery of testosterone.
Pearls & Perspectives: Updates in testosterone therapy, with Andrew Sun, MD at AUA 2025
Andrew Sun, MD, joins Pearls & Perspectives to discuss innovative approaches to testosterone therapy for enhanced health outcomes.
UGN-102 positions itself as an alternative to TURBT for low-grade NMIBC
"I would argue that UGN-102 may very well represent a well-tolerated alternative to TURBT as primary treatment for patients with low-grade disease,” says Sandip M. Prasad, MD, MPhil.