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Atlanta-Young men with PSA velocities greater than 0.5 ng/mL/year are at significantly greater risk for prostate cancer, researchers report in a new study. This suggests that the traditional recommendation of a threshold of 0.75 ng/mL/year to distinguish prostate cancer from benign conditions would miss a substantial proportion of prostate cancers among men younger than 60 years of age.

Atlanta-Cryoablation is a feasible treatment option for patients who have failed radiotherapy, especially for those who may not be considered suitable candidates for salvage radical prostatectomy, according to a new study from Canada.

Atlanta-Autologous adipose stem cells lend themselves well to the engineering of bladder smooth muscle and may eventually make the use of gastrointestinal tissue for this purpose obsolete, say researchers from UCLA.

Brisbane, Australia-Small renal masses are a separate entity from renal cell carcinoma, according to Michael Jewett, MD, professor of surgery, University of Toronto, Canada.

Maywood, IL-The addition of a standard four-stitch Burch suspension to the standard sacrocolpopexy surgical procedure in continent women with pelvic organ prolapse produces dramatic reductions in postoperative stress incontinence, according to a large multicenter study directed by physicians at the Loyola University Medical Center. Results of the trial comparing sacrocolpopexy with and without the Burch suspension were sufficiently dramatic to cause the trial directors to stop enrollment at the first interim analysis.

Atlanta-Men who are being treated with androgen deprivation therapy for progressive prostate cancer face a second, less-recognized risk: osteoporosis and bone fracture. An initial report from a 2-year trial shows that weekly treatment with the oral bisphosphonate alendronate (Fosamax) can halt and even reverse the bone loss associated with androgen deprivation therapy.

Atlanta-Stimulation of the pudendal nerve may be an alternative to sacral neurostimulation (SNS) in the treatment of urinary voiding dysfunction. Two recent studies at William Beaumont Hospital in Royal Oak, MI, indicate that pudendal neurostimulation (PNS) significantly improves cystometric parameters and is effective in patients who do not respond to sacral nerve stimulation.

Paris-A combination regimen of tadalafil (Cialis) and slow-release fluoxetine (Prozac) can significantly prolong intravaginal ejaculation latency time (IELT) in patients suffering from premature ejaculation (PE), according to Brazilian researchers.

Atlanta-The first gene therapy treatment for erectile dysfunction could be available as early as 2011.

Atlanta-The population of patients being treated with a penile prosthesis for erectile dysfunction is evolving, with the average patient now being older and having more medical comorbidities compared with less than 20 years ago, according to the results of a nationwide epidemiologic study reported at the annual AUA meeting here.

Paris-Most patients with asymptomatic lower pole calyceal stones can be followed safely without treatment, with a small minority of them requiring surgical intervention in the long-term, according to Turkish researchers who presented the results of a prospective study at the 2006 European Association of Urology annual congress here in Paris.

Paris-Administration of corticosteroid therapy does not significantly increase the expulsion rate of distal ureteral stones. However, the synergistic effect of steroid therapy with concomitant administration of the alpha-blocker tamsulosin (Flomax) increases the effectiveness of tamsulosin, Italian researchers reported at the recent European Association of Urology annual congress here.

Atlanta-When life gives you lemons-or in this case, hypocitraturic nephrolithiasis-make lemonade.

How can neuromodulation be so efficacious? The answer lies in its mechanism of action.

Five states failed the first-ever prostate cancer state-by-statereport card issued by the National Prostate Cancer Coalition.Alabama, Arkansas, Idaho, Mississippi, and Wisconsin did not makethe grade while California, Connecticut, Kansas, and New York allearned As.

Spectrum Laboratory Products, Inc., is initiating a voluntarynationwide recall of the active pharmaceutical ingredienttacrolimus after learning some lots are sub-potent.

One-fourth of hospitalized older patients are given medicallyunnecessary urinary catheters, according to a study conducted attwo Ohio hospitals.

Researchers at Cleveland Clinic and Memorial Sloan-Kettering CancerCenter, New York, have developed a nomogram capable of predictingthe probability of prostate cancer recurrence within 10 years of apatient's surgical treatment.

The investigational drug NX-1207 has shown significant symptomaticimprovement in men with BPH 29 to 34 months after initial treatmentin a long-term, open-label, phase I/II study.

Men age 75 years and older may not benefit from prostate cancerscreening because they are at risk of adverse outcomes fromaggressive treatment of localized disease, according to a studypublished in the American Journal of Medicine (2006;119:418-25).

The urology community is mourning the death of Joseph W. Segura,MD, who died Tuesday, May 23 after a battle with mesothelioma.

Robert C. Flanigan, MD, was named the new secretary of AUA duringthe association's business meeting yesterday. He is professor andchair of urology at the Loyola University Health System, Maywood,IL.

Cook Urological introduced on Tuesday a new biomaterial known asSurgisis ES for the treatment of Peyronie's disease. Surgisis ES isa natural biomaterial that provides a graft that is strong, easy tohandle, easy to use, and biocompatible, the company said. Itsupports the growth of new fully vascularized host tissue in thepenis.

Intraprostatic injection of botulinum toxin type A (Botox) is asafe and effective treatment in patients with symptomatic BPH thatresults in improvements in symptoms and quality of life that maypersist for up to 1 year, researchers from Taiwan said.

Once-a-day tadalafil (Cialis) at dosages ranging from 5 mg to 20 mgproduces measurable benefits in men with BPH and lower urinarytract symptoms, according to a multicenter study presented hereyesterday.

Despite media images depicting middle-aged and older men embracingthe use of phosphodiesterase type-5 inhibitors to correct erectiledysfunction, actual interest and usage in this population isunknown.

Combining the alpha-blocker alfuzosin SR (Uroxatral) with thephosphodiesterase type-5 inhibitor sildenafil citrate (Viagra)appears to produce a greater therapeutic benefit in men with lowerurinary tract symptoms than either drug alone, researchers saidyesterday.

Long-term survival of inflatable penile prostheses (IPPs) that havebeen in use over the past 2 decades is excellent, and thereliability of those devices appears even more promising for theenhanced models that have become more recently available, saidSteven K. Wilson, MD.