Opinion|Videos|February 12, 2025

BOND-003 Trial and Cretostimogene for Treatment of NMIBC

Panelists discuss how cretostimogene grenadenorepvec is an intravesical oncolytic virus therapy targeting BCG-unresponsive bladder cancer through selective replication in tumor cells and immune stimulation via granulocyte-macrophage colony-stimulating factor expression.

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Video content above is prompted by the following:

  • What is cretostimogene grenadenorepvec? Please describe its mechanism of action.
  • Discuss the phase 3 BOND-003 clinical trial investigating the use of the intravesical immunotherapy cretostimogene grenadenorepvec in patients with high-risk, BCG-unresponsive disease that was recently presented at the Society of Urologic Oncology 2024.
  • What are your impressions of the BOND-003 data?

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