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This list of U.S.-based National Institutes of Health trials is derived from the NIH's database and includes phase I-III overactive bladder trials and phase IV BPH trials that are currently recruiting participants. This list is current as of April 19, 2012. For more information, view the complete database at http://ClinicalTrials.gov.

Signs of the sea change to come in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) will be part of the 2012 AUA annual meeting. Next year should bring even more, as the National Institute of Diabetes and Digestive and Kidney Diseases and pharma research get readied for meeting debuts.

The FDA recently issued a complete response letter for Amgen Inc.'s supplemental Biologics License Application for the RANK ligand inhibitor denosumab (XGEVA) to treat men with castration-resistant prostate cancer at high risk of developing bone metastases.

Uroplasty, Inc., has announced that Novitas Solutions (formerly Highmark Medicare Services) informed the Centers for Medicare & Medicaid Services that it has retired the non-coverage provisions concerning posterior tibial nerve stimulation (PTNS) from its local coverage determination effective for services incurred on or after April 9, 2012.

Curious about how the U.S. Preventive Services Task Force's recently drafted recommendation against routine PSA screening for prostate cancer at any age would affect clinical practice, investigators at the University of Chicago Medical Center and UCLA studied the effect of a 2008 task force recommendation against screening in men aged 75 years or older and found there was none.

Excess body weight may be associated with an increased risk for cancer recurrence in men with clinically localized prostate cancer, according to a study presented at the American Association for Cancer Research annual meeting in Chicago.

A recently announced joint strategic partnership between the American College of Surgeons and the Centers for Disease Control and Prevention aims to combine expertise and resources to track, report, and prevent surgical-site infections (SSIs) and other adverse outcomes among surgical patients.

Kidney cancer patients who underwent partial nephrectomy experienced better survival than patients who underwent radical nephrectomy, report researchers from the University of Michigan Comprehensive Cancer Center, Ann Arbor.