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Opinion|Videos|September 4, 2024

Evaluating Cretostimogene: BOND-003 and PIVOT-006 Trial Results

Author(s)Trinity Bivalacqua, MD, PhD, Mark D. Tyson, MD, MPH

Panelists discuss whether the trial results support investigating cretostimogene with other checkpoint inhibitors and provide insights into notable ongoing trials exploring cretostimogene for intermediate- or high-risk NMIBC, such as BOND-003 and PIVOT-006.

Episodes in this series

EP. 1 Prevalence and Staging of Newly Diagnosed Bladder Cancer

EP. 1 Prevalence and Staging of Newly Diagnosed Bladder Cancer

EP. 2 Impact of BCG Therapy Shortage on the Management of High-Risk NMIBC

EP. 2 Impact of BCG Therapy Shortage on the Management of High-Risk NMIBC

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 3 Recurrence and BCG Resistance in High-Risk NMIBC

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 4 Therapies Beyond BCG: FDA-Approved and Emerging Options

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 5 Cretostimogene, Grenadenorepvec, and Pembrolizumab for BCG-Unresponsive NMIBC: Overview of ASCO 2024 Data

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 6 CORE-001 Trial Participation and Eligibility Criteria

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 7 Comparing Cretostimogene and BCG Administration Methods

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 8 Results of the CORE-001 Trial: 24-Month Complete Response Rate and Duration of Response

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 9 Safety Outcomes and Duration of Response in Combination Therapy vs. Monotherapy for BCG UR CIS +/- Papillary Disease

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 10 Evaluating the Benefits of Cretostimogene Plus Pembrolizumab for BCG-Unresponsive NMIBC Management

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 11 Evaluating Cretostimogene: BOND-003 and PIVOT-006 Trial Results

Trinity Bivalacqua, MD, PhD, and Mark Tyson, MD, MPH, experts on bladder cancer

EP. 12 Managing BCG-Unresponsive NMIBC: Cretostimogene Monotherapy vs. Combination Therapy

Video content above is prompted by the following questions:

Do you think the results of this trial support the investigation of cretostimogene in combination with other checkpoint inhibitors?
Can you briefly discuss other notable trials that are investigating cretostimogene for intermediate- or high-risk NMIBC?

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