Cretostimogene, Grenadenorepvec, and Pembrolizumab for BCG-Unresponsive NMIBC: Overview of ASCO 2024 Data
Experts give an overview of the ASCO 2024 data.
EP: 1.Prevalence and Staging of Newly Diagnosed Bladder Cancer
EP: 2.Impact of BCG Therapy Shortage on the Management of High-Risk NMIBC
EP: 3.Recurrence and BCG Resistance in High-Risk NMIBC
EP: 4.Therapies Beyond BCG: FDA-Approved and Emerging Options
EP: 5.Cretostimogene, Grenadenorepvec, and Pembrolizumab for BCG-Unresponsive NMIBC: Overview of ASCO 2024 Data
EP: 6.CORE-001 Trial Participation and Eligibility Criteria
EP: 7.Comparing Cretostimogene and BCG Administration Methods
EP: 8.Results of the CORE-001 Trial: 24-Month Complete Response Rate and Duration of Response
EP: 9.Safety Outcomes and Duration of Response in Combination Therapy vs. Monotherapy for BCG UR CIS +/- Papillary Disease
EP: 10.Evaluating the Benefits of Cretostimogene Plus Pembrolizumab for BCG-Unresponsive NMIBC Management
EP: 11.Evaluating Cretostimogene: BOND-003 and PIVOT-006 Trial Results
EP: 12.Managing BCG-Unresponsive NMIBC: Cretostimogene Monotherapy vs. Combination Therapy
Video content above is prompted by the following question:
The phase 2 CORE-001 trial investigated a new treatment combination of intravesical cretostimogene grenadenorepvec with pembrolizumab in patients with BCG-unresponsive, high-risk NMIBC. Before we review the trial background and results presented at the ASCO 2024 Annual Meeting, can you introduce cretostimogene and describe its mechanism of action?
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