Opinion
Video
Author(s):
A panelist discusses how the outcomes of this study broadly align with real-world treatment patterns and clinical experiences, where enzalutamide and darolutamide both demonstrate efficacy in metastatic hormone-sensitive prostate cancer (mHSPC), although practical considerations such as darolutamide’s more favorable central nervous system (CNS) toxicity profile and enzalutamide’s longer clinical experience often influence prescribing decisions based on individual patient characteristics and comorbidities
Summary for Physicians: Study Outcomes vs Real-World Experience With Enzalutamide and Darolutamide
The relationship between clinical trial results and real-world experience with enzalutamide and darolutamide shows important patterns:
The alignment between trial data and clinical experience supports the use of either agent in mHSPC, with selection increasingly guided by toxicity profiles and patient-specific factors rather than efficacy differences alone.