June 30th 2025
A comprehensive guide to the key regulatory decisions and conferences slated for Q3 of 2025.
FDA expert reviews data supporting belzutifan approval for VHL-associated kidney cancer
November 16th 2023Data from the phase 2 LITESPARK-004 trial led to the FDA approval of belzutifan for patients with von Hippel-Lindau disease who require therapy for associated renal cell carcinoma and other diseases.
Adjuvant pembrolizumab improves overall survival in certain patients with renal cell carcinoma
November 1st 2023Adjuvant pembrolizumab improved overall survival compared with placebo in patients with renal cell carcinoma at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions.
Phase 3 trial of subcutaneous nivolumab in ccRCC meets co-primary end points
October 19th 2023Data showed noninferiority of subcutaneous nivolumab to intravenous nivolumab in the time-average to nivolumab serum concentration over 28 days (Cavgd28) and the trough serum concentration at steady state (Cminss).
Dr. Singla on race-specific outcomes for renal cell carcinoma
October 5th 2023“The goal of our work, essentially, was to leverage a national population-based cancer registry to comprehensively analyze multiple socioeconomic determinants of racial disparities and survival outcomes among nearly 400,000 patients with renal cell carcinoma,” says Nirmish Singla, MD, MSc.
Targeted neoadjuvant therapy for high-complexity cases of renal masses in a solitary kidney
September 2nd 2023A Cleveland Clinic study found that TKIs in the neoadjuvant setting are associated with greater use of partial nephrectomy when treating patients diagnosed with renal masses in a solitary kidney.
Adjuvant pembrolizumab DFS benefit in ccRCC sustained across disease subgroups
August 31st 2023The disease-free survival and distant metastasis-free survival benefits observed with adjuvant pembrolizumab in the intent-to-treat population of patients with clear cell renal cell carcinoma extended across all subgroups defined by disease risk, tumor stage, and lymph node involvement.
Experts discuss future research on functional decline after partial nephrectomy
August 11th 2023"One of the things that we want to look at long-term is how the kidney being exposed to limited durations of warm ischemia compared to no ischemia at all affects longitudinal atrophy," says Carlos Muñoz-Lopez.
Race-modified equations contribute to disparity in partial nephrectomy use in black patients
July 10th 2023“Our findings show that race-modified equations account for some but not all of the disparity in partial nephrectomy use. We need to keep searching for answers to ensure people of all races receive appropriate care," said Christopher Weight, MD.