Two markers miss small percentage of high-grade prostate Ca
December 18th 2019Combining the 4Kscore or ExoDx with multiparametric MRI appears to be the optimal strategy for detecting high-grade prostate cancer, a study from the University of California, San Francisco suggests. However, it is reasonable to consider biomarker testing only in patients who want to avoid biopsy, said first author Claire M. de la Calle, MD.
The case for SBRT as renal cell carcinoma treatment
December 17th 2019Clinicians are taught that renal cell carcinoma is radioresistant, but modalities such as stereotactic body radiation therapy (SBRT) can be safe and efficacious in certain patients with RCC. In this interview, Vitaly Margulis, MD, outlines the advantages of SBRT and offers a preview of the RADVAX trial, which combines radiotherapy and immunotherapy.
How the Cancer Genome Atlas has impacted bladder Ca management
December 17th 2019The Cancer Genome Atlas (TCGA) has provided a “complete genomic roadmap” of muscle-invasive bladder cancer, according to Seth P. Lerner, MD, co-chair of the Analysis Working Group of the TCGA program for muscle-invasive bladder cancer. Dr. Lerner talks to Urology Times about the clinical relevance of the TCGA’s findings, possible implications for upper tract disease, and what further research is needed.
What is cytoreductive nephrectomy’s current role in RCC treatment?
December 17th 2019The introduction of targeted therapies and immunotherapies has generated uncertainty regarding the role of the cytoreductive nephrectomy in the treatment of metastatic renal cell carcinoma. In this interview, Hyung L. Kim, MD, discusses the recent CARMENA and SURTIME clinical trials, and outlines the upcoming SWOG-1931 trial.
Agent for high-grade NMIBC meets primary endpoint in phase III trial
December 16th 2019In a pivotal phase III study, more than half of patients with high-grade nonmuscle-invasive bladder cancer (carcinoma in situ ± Ta/T1) receiving nadofaragene firadenovec achieved a complete response at 3 months, reported lead author Colin P.N. Dinney, MD.
Prostate cancer surveillance found safe at 17 years
December 12th 2018“Over the past few decades, the rate of active surveillance has been around 10%. Now in recent years, the rate of active surveillance is 55% across the U.S. So times are changing," says Sigrid Carlsson, MD, PhD, MPH, in this interview.
CARMENA trial is not final word on cytoreductive nephrectomy
December 10th 2018In a video interview with Urology Times, Robert C. Flanigan, MD, points out the shortcomings of the CARMENA trial, patient selection for cytoreduction, and the future of cytoreductive nephrectomy in the age of PD-1 inhibitors.