Videos

Mark D. Tyson II, MD, MPH, contextualizes the cretostimogene data within the broader BCG-unresponsive NMIBC treatment landscape, addresses the methodologic limitations of cross-trial comparison, discusses the heavily pretreated nature of the BOND-003 population, reviews his approach to treatment sequencing across available bladder-sparing options, and offers his central take-home message for urologists managing high-risk BCG-unresponsive disease.

Mark D. Tyson II, MD, MPH, reviews the safety and tolerability profile of cretostimogene in BOND-003, including the absence of grade 3 or higher treatment-related adverse events, a 97% protocol completion rate, and the practical workflow considerations that would govern administration of cretostimogene in a urology practice if the agent receives FDA approval.