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Opinion|Videos|December 25, 2024

Gene Therapy Data for BCG-Unresponsive NMIBC

Key Takeaways

  • BCG-unresponsive NMIBC is defined by persistent or recurrent high-grade tumors or carcinoma in situ after adequate BCG therapy.
  • This condition requires alternative therapeutic strategies or radical cystectomy due to the failure of BCG treatment.
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Katie S. Murray, DO, discusses the promising clinical trial data showing that over 50% of patients with BCG-unresponsive non–muscle-invasive bladder cancer (NMIBC) experience a complete response after 3 months of treatment, comparing these outcomes with her own clinical experience, and highlights the importance of long-term follow-up to assess the durability of response in patients receiving newer therapies.

Episodes in this series
  1. Data for newer therapies have shown that more than 50% of patients with BCG-unresponsive NMIBC experience a complete response after just 3 months of treatment. What are your thoughts on these findings?
    1. How do these clinical trial outcomes compare with what you see in your clinical practice when treating patients with newer therapies
  2. Discuss the importance of long-term follow-up for patients receiving these newer treatments.
    a. What is your experience in terms of durability of response?

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