Bladder Cancer

"It is essential for us to be vigilant about all the complications, whether local or systemic, associated with intravesical BCG," writes Badar M. Mian, MD.

A 4-week hypofractionated radiotherapy course was associated with a lower risk of bladder cancer recurrence compared with a 6.5-week standard treatment course.

The investigational padeliporfin ImPACT platform involves the intravenous delivery of the photosensitive drug padeliporfin, which is then activated by a non-thermal light delivery system.

The collaboration will focus on the novel combinatorial intravesical immunotherapy UGN-302 as a potential treatment for patients with high-grade non-muscle invasive bladder cancer.

Disease stage and adverse features were the main predictors of relapses and survival after robot-assisted radical cystectomy.

Register for a live, interactive event featuring leaders in oncology reviewing and discussing patient cases in Bladder Cancer/Renal Carcinoma.

Vikram M. Narayan, MD, discusses the high complete response rate and manageable safety profile with nadofaragene firadenovec in BCG-unresponsive non-muscle invasive bladder cancer.

The approval was based on findings from the phase 3 JAVELIN Bladder 100 study.

Vikram M. Narayan, MD, discusses how smoking is the most significant known risk factor for bladder cancer.

The combination of eganelisib and nivolumab demonstrated promising activity and was well tolerated in a phase 2 trial of patients with advanced urothelial cancer.

The paper is meant to serve as a single source of information for helping patients with bladder cancer.

Combining the novel interleukin-15 superagonist complex N-803 (Anktiva) with BCG led to a high complete response rate in patients with BCG-unresponsive, high-risk, non-muscle invasive bladder cancer with carcinoma in situ.

Gomella looks back on the year's top headlines in bladder cancer, from FDA approvals to notable clinical trial results.

Dr. Vikram M. Narayan describes treatment advances and next steps in non-muscle invasive bladder cancer.

The PD-L1 inhibitor has been recommended for approval in this setting based on data from the phase 3 JAVELIN Bladder 100 study.

The phase 2 study has a targeted enrollment of 37 patients and a primary end point of complete response.

Experts in prostate cancer, bladder cancer, kidney stones, OAB/incontinence, BPH, and sexual dysfunction recap all the key advances from 2020.

“These data published in the Lancet Oncology show that nadofaragene firadenovec, a first-of-its-kind therapy, may be an effective treatment option for BCG-unresponsive non-muscle invasive bladder cancer patients,” Colin P. N. Dinney, MD.

Improvement in imaging modalities may help in performance of transurethral resection of the bladder tumor.

The new fixed-dose schedule is approved for all of durvalumab's FDA indications, including advanced bladder cancer.

UGN-102 (mitomycin) for intravesical solution induced long-lasting complete responses in patients with low-grade intermediate-risk non-muscle invasive bladder cancer.

Scott T. Tagawa, MD, highlighted pivotal data for enfortumab vedotin and sacituzumab govitecan at the 38th Annual CFS meeting.

“There is an urgent need for novel therapies in BCG-unresponsive disease. While standard cystectomy is highly curative, it is associated with a substantial risk for morbidity and non-trivial mortality,” said Arjun Balar MD.

In this interview, Seth P. Lerner, MD, discusses current recommendations for managing patients during the BCG shortage, what the FDA is doing to resolve the problem, and a SWOG trial testing a new strain of BCG.

In patients with muscle-invasive bladder cancer, gemcitabine plus once daily radiation showed a low cystectomy rate and high overall survival rate at long-term follow-up.

Stephen B. Williams, MD, MS, discusses a recent study evaluating costs of surgical treatments for bladder cancer.

Program encompasses patient counseling, anesthetic planning, and early mobilization.

Presurgical treatment with the PD-L1 inhibitor durvalumab and the CTLA-4 inhibitor tremelimumab showed promise in cisplatin-ineligible patients with high-risk localized bladder cancer.

The antibody-drug conjugate was highly active in patients who received a PD-1/PD-L1 inhibitor but were ineligible for cisplatin.

The sensitivity rate for the detection of urothelial carcinoma with the UroCAD urine-based liquid biopsy far exceeded the rate with urine cytology.