Bladder Cancer

Investigational agents on the horizon include Vicineum, nadofaragene firadenovec, and N-803 (Anktiva).

The treatment paradigm in upper tract urothelial carcinoma (UTUC) is rapidly evolving, particularly with the FDA approving mitomycin gel (Jelmyto) as the first therapy to treat low-grade UTUC.

Case study of a patient with muscle-invasive bladder cancer.

A search of a legal database found 42 cases related to cystectomy over a 30-year period.

The safety and efficacy of the locally administered fusion protein were assessed in the phase 3 VISTA trial.

The investigational padeliporfin ImPACT platform involves the intravenous delivery of the photosensitive drug padeliporfin, which is then activated by a non-thermal light delivery system.

The withdrawal comes after the confirmatory phase 3 IMvigor211 study missed its primary end point.

Treatment following progression on chemotherapy and an immune checkpoint inhibitor remains an unmet medical need.

Shaakir Hasan, DO, discusses socioeconomic characteristics associated with the diagnosis and management of bladder cancer.

The subgroup analysis assessed data from the pivotal phase 3 JAVELIN Bladder 100 trial showed.

“[Urologists are] very comfortable giving agents in the bladder, so [CG0070] really fits in line with what we give,” says investigator Edward Uchio, MD.

Based on these findings, an application has been filed with the FDA to expand enfortumab vedotin’s approval to include cisplatin-ineligible patients with locally advanced or metastatic urothelial cancer who have been previously treated with a PD-1/L1 inhibitor.

Boorjian anticipates research with nadofaragene firadenovec in settings beyond BCG-unresponsive non-muscle invasive bladder cancer.

"Our study demonstrates the feasibility of HIVEC MMC and suggests it is a reasonable substitute for BCG during global shortages," says urologist Scott P. Campbell, MD.

The withdrawal comes after the confirmatory phase 3 DANUBE trial missed its primary end points.

Adjuvant treatment with the anti–PD-1 immunotherapy significantly extended the time period after primary treatment in which patients had no signs or symptoms of cancer.

Determining grade of disease is important, as nephron-sparing approaches may be feasible.

“The biggest risk that our patients face is a severe COVID-19 episode,” says Kutikov.

Two supplemental Biologics License Applications have been submitted to the FDA for the antibody-drug conjugate.

The safety and efficacy of the locally administered fusion protein were assessed in the phase 3 VISTA trial.

“One of the things that distinguishes this treatment is its patient and provider ease of delivery,” says Boorjian.

"It is essential for us to be vigilant about all the complications, whether local or systemic, associated with intravesical BCG," writes Badar M. Mian, MD.

Williams discusses a study comparing costs for radical versus partial cystectomy.

A 4-week hypofractionated radiotherapy course was associated with a lower risk of bladder cancer recurrence compared with a 6.5-week standard treatment course.