Urology Times staff

Evangelia Sereti, MSc, PhD, discusses the design/methodology and results of a preclinical study exploring the combination of the PARP inhibitor olaparib plus the novel agent NOV202 in BRCA1/2-mutated prostate cancer cells.

“[Prior authorization is] becoming a bigger and bigger problem for each practice,” says urologist Terrence Regan, MD.

Vinayak G. Wagaskar, MBBS, explains the “obesity paradox”—improved survival outcomes in patients with a high body mass index—that has been observed in patients with genitourinary malignancies, including prostate cancer.

Bradley McGregor, MD, explains how despite the groundbreaking immunotherapy-based advances in metastatic renal cell carcinoma, unmet medical needs remain.

“[Prior authorization has] become part of our everyday practicing life, but it does very little to advance quality of care,” says Terrence Regan, MD.

“The key message from this abstract is that the time duration for starting avelumab [Bavencio] maintenance didn't really affect the outcomes,” says Shilpa Gupta, MD.

“The side that can take…complex issues and make them simple…is likely going to be the side that wins in a case,” says Kenton H. Steele, Esq.

Shilpa Gupta, MD, discusses several recent studies in the metastatic urothelial carcinoma space.

Urologists Steven M. Wahle, MD, and Henry Rosevear, MD, catch up with each other in this wide-ranging conversation.

Yousef Zakharia, MD, discusses the design and results of a phase 2 trial that explored concurrent treatment with radiation and the PD-L1 inhibitor durvalumab followed by adjuvant durvalumab in patients with urothelial cancer.

Adjuvant pembrolizumab reduced the risk of disease recurrence or death versus placebo in the phase 3 KEYNOTE-564 trial, but overall survival data are still immature.

Risa Wong, MD, discusses the sequencing of treatments in the metastatic urothelial carcinoma armamentarium, including chemotherapy, immune checkpoint inhibitors, and antibody-drug conjugates.

Although women represent an increasing percentage of the urology workforce, they continue to be underrepresented in receiving recognition awards from the American Urological Association.

"I think [at] the 2021 ASCO annual meeting, we saw a lot of novel data focusing on bladder-preservation approaches," says Shilpa Gupta, MD.

Miron presented a study at the 2021 ASCO Annual Meeting that explored the influence of first-line chemotherapy choice on survival outcomes in patients who received immunotherapy in the second-line setting.

In this video, Shilpa Gupta, MD, discusses the rapidly evolving world of research on urothelial carcinoma.

Miron et al specifically compared the choice between frontline cisplatin plus gemcitabine versus frontline carboplatin plus gemcitabine in patients with advanced urothelial carcinoma.

Between 40% and 50% of patients with mCRPC have loss in PTEN, which is associated with worse prognosis and reduced benefit from AR blockade.

“There are a couple of different important and unique questions that expert witnesses help answer in the context of medical malpractice litigation,” says Kenton H. Steele, Esq.

Seideman says urology is a great option for women considering a surgical subspecialty.

Dr. Neal D. Shore discusses multidisciplinary care in prostate cancer against the backdrop of the ODENZA trial, which assessed patient preference between darolutamide and enzalutamide.

Ranjith Ramasamy, MD, comments on SOV2012-F1 (Kyzatrex), an oral testosterone undecanoate soft gelatin capsule.

“If we allow a cardiologist to be critical of a family medicine practitioner, there's a chance that they're being held to an unreasonable standard that doesn't apply to their day to day, which is why that requirement is in place for most but not all states,” says Kenton H. Steele Esq.

Although women represent an increasing percentage of the urology workforce, they remain underrepresented in receiving recognition awards from the American Urological Association.

"I do think there's a big opportunity, if [telemedicine is] used correctly, to overcome some of these workforce shortages," says Chad Ellimoottil, MD, MS.

Casey Seideman, MD, discusses the gender pay gap in urology and the path forward to address the issue.

Health care providers focus on genomic testing in heavily treated, metastatic castrate-resistant prostate cancer from the multidisciplinary approach to cancer care.

Health care providers focus on genomic testing in newly diagnosed, high grade, high-risk prostate cancer from the multidisciplinary approach to cancer care.

“I think one of the most surprising things to us as we started to look at the data is that we had a very low rate of no shows amongst telemedicine visits,” says Randie White, MD.

A recently published study showed an increased risk of cardiac failure in men with BPH and exposure to 5-alpha reductase inhibitors and/or α-blockers.