Videos

"Outside a randomized trial, we cannot make any conclusion about the causal relationship between conducting cytoreductive nephrectomy and improved outcomes," says Jaleh Fallah, MD.

"It's really interesting to see how potentially these differentially expressed genes could suggest a different biology based on the zone that they arose from," says Zeyad Schwen, MD.

"I would say the biggest take-home is that for Hispanic patients, there's a reduced likelihood of a successful fertility outcome that has been observed in an area that is enriched with a Hispanic population that's comparable to that of the US," says Devon M. Langston, MD.

“The first one [is] we confirmed the prognostic value of KIM-1. Overall, in INmotion010, patients with high KIM-1 clearly had a higher risk of recurrence,” says Laurence Albiges, MD, PhD.

"When looking at individual vaginal estrogen products prescribed by OB-GYNs median spending per claim for Vagifem and Yuvafem decreased and median spending per claim increased for Estrace and Estring," says Alexandra Tabakin, MD.

“We are trying to evaluate the ctDNA role in prognostication as well,” says Chinmay Jani, MD.

Steven Finkelstein, MD, FACRO, discusses PSMA-PET imaging practices for patients experiencing biochemical recurrence.

Experts on prostate cancer offer clinical insights on identifying the appropriate patients for PSMA-PET imaging.

The panel discusses data on the accuracy of MRI-targeted or fusion-based biopsy procedures compared with systemic biopsy or MRI alone.

"When controlling for demographic and clinical factors, the number of live births was reduced for Hispanic men," says Devon M. Langston, MD.

Firas F. Abdollah, MD, provides insights on how MRI- or fusion-guided technologies are used with transrectal and transperineal biopsy procedures and how they improve traditional biopsy procedures.

Jason Hafron, MD, CMO, provides an overview of the QUILT trial investigating N-803 in patients with BCG-unresponsive high-grade non–muscle invasive bladder cancer.

The panel reviews data from the SunRISe-1 trial investigating TAR-200 and offers its impressions on the efficacy and safety findings.

“It's one thing to recruit diverse talent, but it's really another thing to retain it,” says Alexandra Tabakin, MD.

“We hope that the survey can be helpful in practice to actually assess and give advice to some of these partners of patients, in addition to the questionnaires that we use for the patients themselves,” says Stacy Loeb, MD, MSc.

"The challenge of treating men with high-risk disease and potential micro metastatic disease with this type of targeted therapy is really exciting," says David I. Lee, MD, FACS.

"We found that, in our study, approximately 25% of patients who have had opioids prior to their cystectomy will continue to use opioids 3 to 6 months after their surgery," says Christopher J. Staniorski, MD.

“At the Advocacy Summit earlier this spring, 2 of the 3 leave-behind documents that outlined specific issues related to urology priorities were directly informed by information from the Census,” says Matthew Nielsen, MD, MS, FACS.

"Questions that arise for us [include] why, and what's further contributing to our observed outcome?" says Devon M. Langston, MD.

Expert urologist explores potential treatments for BCG-unresponsive intermediate and high-risk non-muscle-invasive bladder cancer (NMIBC), including immune checkpoint inhibitors, oncolytic viral therapy, cytokine agonists, immunomodulators, and the recently approved drugs pembrolizumab and nogapendekin alfa inbakicept-pmln.

"We found that during the 5-year study period, the total number of claims for vaginal estrogen, the number of prescribers, and the number of beneficiaries decreased," says Alexandra Tabakin, MD.

“I think my immediate hope and goal with the study finding is universal incorporation of HPV testing on all penile cancer patients,” says Rohan Garje, MD.

"Despite the results of SURTIME and CARMENA, among others, we continue to hear discussions about the role of cytoreductive nephrectomy in conferences and literature, suggesting that this remains a question that has not been fully addressed," says Jaleh Fallah, MD.

“The results of the study showed that regardless of any biomarkers, the combination of pembrolizumab and lenvatinib was superior or associated with a better median progression-free survival compared to sunitinib,” says Jaime R. Merchan, MD.

“We can see that the median survival is going beyond 31 months, meaning that patients with a low tumor burden are benefiting,” says Joaquim Bellmunt, MD, PhD.

"There is a hypothesis that nectin-4 as a potential target for antibody drug conjugates, such as EV, potentially should work," says Marijo Bilusic, MD, PhD.

“So, we split this apart and looked into if the type of progression would occur differently depending on the organ sites, which it did not. What we have seen is maintained benefits for the combination of lenvatinib and pembrolizumab vs sunitinib,” says Viktor Grünwald, MD, PhD.

“My hope is that the DFF332 approach may potentially be one that's palatable in combination with other therapies,” says Sumanta Pal, MD, FASCO.

Focusing on prostate cancer diagnosis, the panel discusses transrectal and transperineal biopsies and limitations associated with them.

The panel discusses the role of PSMA-PET imaging in prostate cancer and highlights different PSMA agents.