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The FDA has accepted for review Urovant Sciences’ New Drug Application for once-daily 75 mg vibegron for the treatment of patients with overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.

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A significant trend is occurring in the management of urethral stricture, with increased utilization of urethroplasty and decreased utilization of repeat endoscopic procedures, researchers at the University of Washington in Seattle report.

Rita P. Jen, MD, MPH

“Although the raw number of augmentations and diversions have been relatively unchanged, the proportion of patients undergoing both surgeries declined while the proportion of patients undergoing Botox injections doubled over the past 5 years,” said Rita P. Jen, MD, MPH.

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November 2019 proved to be a fruitful month for urology-specific FDA approvals, with the agency giving the green light to a new drug for complicated urinary tract infection, an implantable device for the treatment of overactive bladder/retention, and a digital product for strengthening of pelvic floor muscles and treatment of urinary incontinence in women.

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Selective bladder denervation, which targets the afferent nerves at the trigone only, appears to be an effective treatment for refractory overactive bladder patients, lasting up to 12 months regardless of whether the patient exhibits detrusor overactivity at baseline, according to a recent study from Canada.

Image courtesy of the Wake Forest Institute for Regenerative Medicine

Patients with urologic conditions have easy access to stem cell therapy options offered by a spectrum of providers at locations that vary from strip mall clinics to academic centers. But while there’s hope that cell-based therapies might not only treat symptoms but also modify diseases, including erectile dysfunction, the scientific evidence to show therapies using any stem cells work and don’t cause harm is lacking.

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As the number of patients who receive onabotulinumtoxinA (onabotA [Botox]) injections for overactive bladder increases, so does the age of this population and their associated comorbidities. This raises the question: Is the use of onabotA in patients who are taking anticoagulant or antiplatelet medication safe?

Sandip Vasavada, MD

In this video, Sandip Vasavada, MD, of the Center for Female Urology and Reconstructive Pelvic Surgery, Cleveland Clinic, explains how the recently updated AUA/SUFU clinical guideline for overactive bladder helps urologists treat the condition.